Animal comfort

Information on how to better manage pain in research animals

The following articles have been selected by panel members of ANZCCART to help researchers and AEC members improve their understanding of anaesthesia in research animals.

Resources on how to improve anaesthesia in research animals

  • Richebé, Philippe, et al. “Ketamine improves the management of exaggerated postoperative pain observed in perioperative fentanyl-treated rats.”Anesthesiology 102.2 (2005): 421-428. (Read the Richebe Abstract)
  • Langford, Dale J., et al. “Coding of facial expressions of pain in the laboratory mouse.” Nature methods 7.6 (2010): 447-449. (Read the Langford Abstract)

Information on anaesthesia in research animals

The following articles have been selected by panel members of ANZCCART to help researchers and AEC members improve their understanding of anaesthesia in research animals.

For a selection of resources we recommend publications by Paul Flecknall such as Anaethesia in research animals.

Resource links on anaesthesia in research animals

  • Saha, Joy K., et al. “Acute hyperglycemia induced by ketamine/xylazine anesthesia in rats: mechanisms and implications for preclinical models.”Experimental Biology and Medicine 230.10 (2005): 777-784. (Read the Saha Abstract)
  • Eintrei, Christina, L. Sokoloff, and C. B. Smith. “Effects of diazepam and ketamine administered individually or in combination on regional rates of glucose utilization in rat brain.” British journal of anaesthesia 82.4 (1999): 596-602. (Read the Eintrei Abstract)
  • Curtin, Leslie I., et al. “Evaluation of buprenorphine in a postoperative pain model in rats.” Comparative medicine 59.1 (2009): 60. (Read the Curtin Abstract)
  • Toth, Linda A. “Defining the moribund condition as an experimental endpoint for animal research.” ILAR Journal 41.2 (2000): 72-79. (Read the Toth Abstract)